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Abnormal mitochondrial fission results in mitochondrial fragmentation, triggering depolarization, oxidative stress, and ultimately severe neuronal damage (Santos et al., 2015

15 Fitly, P-gp participates in the formation of cell membranes and increases the negative charges on the surface of the tumor cell membrane, which is conducive to the combination of cationic AMPs and drug-resistant tumor cell membranes, thereby better exerting anti-cancer activity

Proponents of combining NAD+ supplementation with tirzepatide suggest several theoretical benefits, though it is crucial to emphasize that these potential synergies are largely speculative and not supported by clinical trial evidence